We sought to assess formally the extent to which different control and elimination strategies for human African trypanosomiasis Trypanosoma brucei gambiense would exacerbate or alleviate experiences of societal disadvantage that traditional economic evaluation does not take into account. Justice-enhanced cost-effectiveness analysis is a normative approach under development to address social justice considerations in public health decision-making alongside other types of analyses. It aims to assess how public health interventions under analysis in comparative evaluation would be expected to influence the clustering (...) of disadvantage across three core dimensions of well-being: agency, association and respect. As a case study to test the approach, we applied it to five strategies for Gambiense HAT control and elimination, in combination with two different other evaluations: a cost-effectiveness analysis and a probability of elimination analysis. We have demonstrated how JE-CEA highlights the ethical importance of adverse social justice impacts of otherwise attractive options and how it indicates specific modifications to policy options to mitigate such impacts. JE-CEA holds promise as an approach to help decision makers and other stakeholders consider social justice more fully, explicitly and systematically in evaluating public health programs. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

This paper argues that research on normative issues in the life sciences will benefit from a tighter integration of philosophy of science. We examine research on ethical, legal and social issues in the life sciences (“ELSI”) and discuss three illustrative examples of normative issues that arise in different areas of the life sciences. These examples show that important normative questions are highly dependent on epistemic issues which so far have not been addressed sufficiently in ELSI, RRI and related areas of (...) research. Accordingly, we argue for the integration of research on the epistemic aspects of the relevant areas of science into ELSI research to provide a better basis for addressing normative questions. (shrink)

The term “lean in” was popularized by Sheryl Sandberg, Facebook COO, via her #1 Best Seller encouraging women to defy their fears and dare to be leaders in their fields. She received criticism because although admitting to external barriers contributing to the gender gap in leadership, the scope of her book focused on the internal shortcomings of women. She asserted that women are hindered by barriers that exist within themselves, and provided practical tips, backed by research, to equip women with (...) strategies to proactively progress in the workplace instead of shying away. Sandberg is not the first to raise concern about gender inequality. Other women in history like Susan B. Anthony and Maggie Lena Walker also challenged lopsided gender roles through their words and actions. Using the critical biography methodology, this paper explores these women’s experiences, philosophies and contributions, reflects on Sandberg’s insight, and develops a framework, based on the theory of planned behavior as well as the ethical principles of utilitarianism and corporate social responsibility, that links internal factors, organizational external factors, and societal external factors to intentions to lean in and leaning in behavior. Thus, via critical biography, this paper examines both internal and external factors, showing how they are linked, and how they may impact leaning in intentions and behavior. The paper also discusses how leaning in may influence both individual and gender mobility for women, and ultimately, increased gender equality. (shrink)

Sound symbolism refers to non‐arbitrary mappings between the sounds of words and their meanings and is often studied by pairing auditory pseudowords such as “maluma” and “takete” with rounded and pointed visual shapes, respectively. However, it is unclear what auditory properties of pseudowords contribute to their perception as rounded or pointed. Here, we compared perceptual ratings of the roundedness/pointedness of large sets of pseudowords and shapes to their acoustic and visual properties using a novel application of representational similarity analysis (RSA). (...) Representational dissimilarity matrices (RDMs) of the auditory and visual ratings of roundedness/pointedness were significantly correlated crossmodally. The auditory perceptual RDM correlated significantly with RDMs of spectral tilt, the temporal fast Fourier transform (FFT), and the speech envelope. Conventional correlational analyses showed that ratings of pseudowords transitioned from rounded to pointed as vocal roughness (as measured by the harmonics‐to‐noise ratio, pulse number, fraction of unvoiced frames, mean autocorrelation, shimmer, and jitter) increased. The visual perceptual RDM correlated significantly with RDMs of global indices of visual shape (the simple matching coefficient, image silhouette, image outlines, and Jaccard distance). Crossmodally, the RDMs of the auditory spectral parameters correlated weakly but significantly with those of the global indices of visual shape. Our work establishes the utility of RSA for analysis of large stimulus sets and offers novel insights into the stimulus parameters underlying sound symbolism, showing that sound‐to‐shape mapping is driven by acoustic properties of pseudowords and suggesting audiovisual cross‐modal correspondence as a basis for language users' sensitivity to this type of sound symbolism. (shrink)

“Work–life balance” is a relatively modern expression. However, there is no novelty in the core concept, as resistance to excessive incompatibility between work roles and personal roles has a history that predates contemporary struggles for a decline in unnecessary work–life conflict. The authors of this manuscript aim to convey a portion of this history by instilling, from an ethics perspective, an awareness of the efforts of early labor organizations, including labor unions, and a social organization that addressed labor issues. They (...) will also communicate the resolve of key individuals, especially women, including labor leaders and activists, who contributed to labor reform and served as early proponents for WLB. In addition, implications and suggestions for practice and future inquiry will be provided. (shrink)

Advances in artificial intelligence, as well as its increased presence in everyday life, have brought the emergence of many new phenomena, including an intriguing appearance of what seems to be a variant of body dysmorphic disorder, coined “Snapchat dysmorphia”. Body dysmorphic disorder is a DSM-5 psychiatric disorder defined as a preoccupation with one or more perceived defects or flaws in physical appearance that are not observable or appear slight to others. Snapchat dysmorphia is fueled by automated selfie filters that reflect (...) unrealistic sociocultural standard. In this paper, we discuss how body dysmorphic disorder and related body image distortions could arise, using the conceptual resources provided by the active inference framework. We suggest that these disorders involve dysfunctional self-modelling which entails maladaptive internalization of sociocultural preferences during adolescent identity formation. Identity formation is hereby described as cycles of interpersonal active inference that arbitrate between identity exploration and commitment. We propose that impaired self-modelling is unable to reduce interpersonal uncertainty during identity exploration, which, over time, degenerates into uncontrollable epistemic habits that isolate the body image from corrective sensory evidence. In light of these insights, we subsequently explore some of the consequences of image-centered social media platforms on the identity formation process. We conclude that heightened interpersonal uncertainty in this novel context could precipitate the onset of body dysmorphic disorder and related body image distortions, particularly when selfie filters are involved. (shrink)

Advances in artificial intelligence, as well as its increased presence in everyday life, have brought the emergence of many new phenomena, including an intriguing appearance of what seems to be a variant of body dysmorphic disorder, coined “Snapchat dysmorphia”. Body dysmorphic disorder is a DSM-5 psychiatric disorder defined as a preoccupation with one or more perceived defects or flaws in physical appearance that are not observable or appear slight to others. Snapchat dysmorphia is fueled by automated selfie filters that reflect (...) unrealistic sociocultural standard. In this paper, we discuss how body dysmorphic disorder and related body image distortions could arise, using the conceptual resources provided by the active inference framework. We suggest that these disorders involve dysfunctional self-modelling which entails maladaptive internalization of sociocultural preferences during adolescent identity formation. Identity formation is hereby described as cycles of interpersonal active inference that arbitrate between identity exploration and commitment. We propose that impaired self-modelling is unable to reduce interpersonal uncertainty during identity exploration, which, over time, degenerates into uncontrollable epistemic habits that isolate the body image from corrective sensory evidence. In light of these insights, we subsequently explore some of the consequences of image-centered social media platforms on the identity formation process. We conclude that heightened interpersonal uncertainty in this novel context could precipitate the onset of body dysmorphic disorder and related body image distortions, particularly when selfie filters are involved. (shrink)

CHAPTER Emotional Cognition An introduction Simon C. Moore and Mike Oaksford There has been a marked shift in the perceived role of emotion in human ...

We make two major comments. First, negative reinforcement contingencies may generate some apparent “drug-like” aspects of money motivation, and the operant account, properly construed, is both a tool and drug theory. Second, according to Lea & Webley (L&W), one might expect that “near-money,” such as frequent-flyer miles, should have a stronger drug and a weaker tool aspect than regular money. Available evidence agrees with this prediction. (Published Online April 5 2006).

Developing social skills is essential to succeed in social relations. Two important social constructs in middle childhood, prosocial behavior and reactive aggression, are often regarded as separate behaviors with opposing developmental outcomes. However, there is increasing evidence for the co-occurrence of prosociality and aggression, as both might indicate responsivity to the social environment. Here, we tested whether a bi-dimensional taxonomy of prosociality and reactive aggression could predict internalizing and externalizing problems over time. We re-analyzed data of two well-validated experimental tasks (...) for prosociality and reactive aggression in a developmental population sample. Results revealed no associations between prosociality and reactive aggression, confirming the independence of those constructs. Interestingly, although prosociality and reactive aggression independently did not predict problem behavior, the interaction of both was negatively predictive of changes in externalizing problems over time. Specifically, only children who scored low on both prosociality and reactive aggression showed an increase in externalizing problems 1 year later, whereas levels of externalizing problems did not change for children who scored high on both types of behavior. Thus, our results suggest that at an individual level, reactive aggression in middle childhood might not always be maladaptive when combined with prosocial behavior, thereby confirming the importance of studying social competence across multiple dimensions. (shrink)

Many environmental ills derive from humanity’s unsustainable fondness for meat, a fondness that often pushes (and sometimes breaks) environmental limits and reveals unsustainable patriarchal ideologies. Han Kang’s The Vegetarian and Ang Li’s The Butcher’s Wife each, in very different ways, expose the strands of “meat and gender” enmeshments in Korea and Taiwan respectively, showing the mutual interdependence of carnivorism and patriarchal power. So deeply rooted are the entangled strands of carnivorism and sexism that contesting them (either together or apart) means (...) dismantling the very definition of human corporeality: in The Vegetarian, this means that a woman becomes a plant; in The Butcher’s Wife, it means that a man becomes the very cattle he has spent his life slaughtering; in both, questioning meat is a very dangerous challenge that comes from a woman through a narrative perspective that is clearly feminist. Both novels plainly show deep analogies and correspondences between domestic violence and violence against animals, and yet, in both, there is a taut relationship between vegetable-based histories and a more meat-based modernity. This article argues firstly that the violence of meat-eating in The Vegetarian and The Butcher’s Wife is both physical and psychological. Dreams and madness are involved. Normalcy is male, deviance female. Order is meat, chaos vegetal. And the threat of death will either be fully realized or will hang menacingly in the air. Secondly, this article argues that the novels importantly show that breaking points (psychological and environmental) are often utterly unpredictable and that once breached, the results can also be devastatingly unpredictable. (shrink)

: All known life requires phosphorus (P) in the form of inorganic phosphate (PO43x or Pi) and phosphate-containing organic molecules. Pi serves as the backbone of the nucleic acids that constitute genetic material and as the major repository of chemical energy for metabolism in polyphosphate bonds. Arsenic (As) lies directly below P on the periodic table and so the two elements share many chemical properties, although their chemistries are sufficiently dissimilar that As cannot directly replace P in modern biochemistry. Arsenic (...) is toxic because As and P are similar enough that organisms attempt this substitution. We hypothesize that ancient biochemical systems, analogous to but distinct from those known today, could have utilized arsenate in the equivalent biological role as phosphate. Organisms utilizing such ‘ weird life ’ biochemical pathways may have supported a ‘ shadow biosphere ’ at the time of the origin and early evolution of life on Earth or on other planets. Such organisms may even persist on Earth today, undetected, in unusual niches. (shrink)

We argue that the self-experimentation espoused by Roberts as a means of generating new ideas, particularly in the area of mood, may be confounded by the experimental procedure eliciting those affective changes. We further suggest that ideas might be better generated through contact with a broad range of people, rather than in isolation.

Rolls defines emotion as innate reward and punishment. This could not explain our results showing that people learn faster in a negative mood. We argue that what people know about their world affects their emotional state. Negative emotion signals a failure to predict negative reward and hence prompts learning to resolve the ignorance. Thus what you don't know affects how you feel.

The topics of Anthropocene literature have a perceived global relevance that is greater than that of literature in any other period in history, and Indra Sinha’s Animal’s People, Rohinton Mistry’s A Fine Balance, and Paulo Bacigalupi’s The Windup Girl show this clearly. These books hit common global registers, at once dealing with issues such as urbanization, corporate capitalism, and climate change as common concerns while vigorously valuing and affirming cultural heterogeneity. The topics of these novels virtually guarantee their position as (...) world literature. Sinha, Mistry, and Bacigalupi offer hope rather than doom-and-gloom on topics that are of pressing global concern. In the process, they reveal that Anthropocene fiction has, by its very topicality, a propensity to being world literature, whatever the greatness or weakness of its national origin. Theorizing about world literature thus needs to grapple more decisively than it has with what cli-fi and Anthropocene fiction offer. (shrink)

Literature has an ethical obligation to respond to the climate change crisis, and scholars have a responsibility to understand how these responses work. Neither the humanities nor the sciences have a good record when it comes to encouraging people to limit their desires, their consumption, or their growth. While there may be genetic reasons for this failure, calls for humanity to limit itself need better responses. Literature can help us to respond better to climate change, but only if we reconceptualize (...) narrative and accord to it the importance it once held as a source not only of entertainment but of knowledge necessary for our very survival. (shrink)

This paper argues that food security is a very important topic in cosmopolitanism, one that has simply not received the kind of attention that it should receive. The paper reveals how global food monopolies destroy possibilities for national self-sufficiency, raises questions about neo-nationalism in an age of terror, and exposes the insidious and invidious corporate neo-imperialism that attends seed patenting. “Food, eating, and ethics” as a topic is rarely seen as a proper or important part of discussions about “the new (...) cosmopolitanism,” let alone as part of literary discussions. This paper examines the violence and barbarity of transnational corporations such as Monsanto. I show what happens in the global supermarket and how lives and livelihoods are at stake, how the new corporate imperialism swallows up traditions and histories, and how dangerous food has become. (shrink)

Issues about heritage, knowledge, and memory are central to climate change narratives. In an age when reality television stars become world leaders, the urgency of climate change narratives requires us to understand the crucial roles of memory and heritage to the future of our planet. The sanctity of knowledge simply cannot be abandoned. Knowledge slips away through the cracks, both in mainstream media efforts to sell its news and in the nonchalance of the admittedly more mindful scholars and popularizers of (...) climate change narratives. We face complex issues here, and there is an urgent need to reassess the value systems and ethics that brought us to where we are in terms of climate change. This is no easy task. To face this complex and controversial issue will require tremendous care with facts, honesty about heritage, and commitment to remembering. It will also need recognition of the painful fact that heritage can no longer be an excuse for continued derogation of the natural environment. (shrink)

This paper argues that garbage is no longer the site of contempt and fear and has become an object of profound theoretical investigation. The paper reviews some of the salient points in the growing body of theory about garbage and shows that if one thing has come out of this scholarship, it is that waste is both productive and dangerous, spent but agential, rejected but inescapable, and the intensity of disruptions of order potential in waste are immense. I show that (...) two very different poems – one entitled “Above the Water, Under the Water” by South Korean poet Choi Sung-ho, the other entitled “Garbage” by American poet A.R. Ammons –reveal in very different ways both the agentic capacity of garbage and the ascension of garbage to a semiotics of the sublime in the twentieth century, East and West. (shrink)

The startle reflex provides a revealing model for examining the ways in which evolved neurophysiology shapes personal experience and patterns of recurrent social interaction. In the most diverse cultural contexts, in societies widely separated by time and space, the inescapable physiology of the reflex both shapes the experience of startle and biases the social usages to which the reflex is put. This book describes ways in which the startle reflex is experienced, culturally elaborated, and socially used in a wide variety (...) of times and places. It offers explanations both for the patterned commonalities found across cultural settings and for the differences engendered by diverse social environments. Boo! will intrigue readers in fields such as psychological anthropology, medical anthropology, general cultural anthropology, social psychology, cross-cultural psychiatry, evolutionary psychology, and human ethology. (shrink)

Extreme conditions like savantism, autism or synaesthesia, which have a neurological 2AH, UK basis, challenge the idea that other minds are similar to our own. In this paper we report a single case study of a man in whom all three of these conditions co-occur. We suggest, on the basis of this single case, that when savantism and synaesthesia co- occur, it is worthwhile testing for an undiagnosed Autism Spectrum Condition (ASC). This is because savantism has an established association with (...) ASC, and the combination of ASC with synaesthesia may increase the likelihood of savantism. The implications of these conditions for philosophy of mind are introduced. (shrink)

This Element considers the relationship between the traditional view of God as all-powerful, all-knowing and wholly good on the one hand, and the idea of human free will on the other. It focuses on the potential threats to human free will arising from two divine attributes: God's exhaustive foreknowledge and God's providential control of creation.

We theorize that, in the current development of business ethics, there is a fruitful evolution that dissolves the dichotomy between the normative and behavioral research approaches developed, respectively, by philosophers and social scientists; this approach avoids many of the limitations originated by such distinction by reconnecting their two separate narratives. We call this emerging research model Humanistic Business Ethics (HBE) as it emphasizes the centrality of the human dimension of business and the importance of adopting a richer concept of humanity (...) in business ethics research. We argue that this specific research model in business ethics emerges when scholars combine a pragmatist philosophical approach with some key ideas coming from stakeholder theory, which we summarize and connect. By leveraging collaboration across ethics, economics, psychology, and entrepreneurship, HBE can help business and society scholars undertake fruitful inquiries into the way business works (and should work) at its best. (shrink)

The hard problem of consciousness is the question how subjective experience arises from brain matter. I suggest that quantum physics may be part of the answer. The simultaneous unity and complexity of subjective experience is very difficult to understand from a classical physics perspective. In contrast, quantum entanglement is naturally both complex and holistic. Building on recent remarkable progress in quantum technology and neuroscience, I propose a concrete hypothesis as a basis for further investigation, namely that subjective experience is related (...) to the dynamics of a complex entangled state of spins, which is continuously generated and updated through the exchange of photons. The proposed hypothesis raises many interesting experimental and theoretical questions in neuroscience, quantum physics, evolutionary biology, psychophysics, and philosophy. (shrink)